Juvenile Myelomonocytic Leukemia with t(3;5)(q24;q34), Auer Rods, and Marked Myelodysplasia
نویسندگان
چکیده
منابع مشابه
Auer Rods in Chronic Myelomonocytic Leukemia Can Change the Diagnosis
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with overlapping morphological features of myelodysplastic and myeloproliferative disease and a potential risk of transformation to acute myeloid leukemia. Presence of Auer rods in CMML is a rare finding and the presence of an occasional Auer rod gives the diagnosis of CMML-2 in spite of the presence of <5% blas...
متن کاملAuer rods in a patient with chronic myelomonocytic leukemia type 2.
A 69-year-old man presented with anemia (hemoglobin, 77 g/L), thrombocytopenia (platelets, 84 3 10 /L), and leukocytosis (white blood cell count, 31 3 10/L) including monocytosis (2.61 3 10/L). Blood film showed a leukoerythroblastic picture with nucleated red cells and blasts. Neutrophils had dysplastic features such as hyposegmented and hypersegmented nuclei, rare circular nuclei, and hypogra...
متن کاملJuvenile myelomonocytic leukemia.
A was less than 4 years, with any type of myelodysplasia and monosomy 7. All other patients, including older children BOUT 40 YEARS ago two forms of chronic myelocytic leukemia (CML) were recognized in children. One had the typical features of CML of adulthood and usually with monosomy 7, were classified according to FAB criteria. The revised classification led the authors to propose a new appe...
متن کاملPEDIATRIC HEMATOLOGY Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare clonal myeloproliferative disorder (MPD) of early childhood [1]. The median age at diagnosis is 2 years [1]. There is a male predominance with a male:female ratio of 2:1. Pallor, fever, infection, skin bleeding and cough are the most common presenting symptoms. Typically, there is marked hepatosplenomegaly. JMML rarely involves the central nervo...
متن کاملJuvenile myelomonocytic leukemia and Noonan syndrome.
A case of juvenile myelomonocytic leukemia (JMML, previously referred to as JCML) in a neonate with Noonan syndrome (NS) is described. The boy presented with bilateral congenital hydrothoraces, nonimmune hydrops, dysmorphic facies, persistent thrombocytopenia, and leukocytosis. The diagnosis of JMML was made on bone marrow cell culture studies. Review of the literature reveals an unusual prepon...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2016
ISSN: 1943-7722,0002-9173
DOI: 10.1093/ajcp/aqw151.009